منابع مشابه
Prediction of Protein Sub-Mitochondria Locations Using Protein Interaction Networks
Background: Prediction of the protein localization is among the most important issues in the bioinformatics that is used for the prediction of the proteins in the cells and organelles such as mitochondria. In this study, several machine learning algorithms are applied for the prediction of the intracellular protein locations. These algorithms use the features extracted from pro...
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Integral membrane proteins that form water-filled channels through membranes often exist as aggregates of similar or identical subunits spanning the membrane. It has been suggested that the insertion into the membrane of the channel-forming domains of the subunits may impart unusual structural features to the membrane-intercalated portions of the protein. To test this proposal, we have investig...
متن کاملStreptococcal M Protein Extracted by Nonionic Detergent
Streptococcal M proteins are antiphagocytic molecules varying immunologically from type to type while maintaining an identical biological effect. The virulence of the group A streptococcus is directly related to the presence of the M antigens on the cell surface and resistance to infection by these organisms is dependent on the presence of opsonic antibodies directed towards the M molecules. Va...
متن کاملLipid/Detergent Interaction Thermodynamics as a Function of Molecular Shape
In dilute aqueous mixtures of the detergent C12EO8 and the phospholipid POPC the phase and partition behavior as well as the transfer enthalpies of the respective molecules between the various states (monomers, bilayers, micelles) have been measured by isothermal titration calorimetry [Heerklotz et al., J. Phys. Chem. 1996, 100, 6764]. To derive more information about the molecular interpretati...
متن کاملDetermination of molecular weight of the protein moiety in protein-detergent complexes without direct knowledge of detergent binding.
Sedimentation equilibrium measurements can be used to determine the molecular weight of the protein moiety of a protein-detergent complex without prior knowledge of detergent binding. The procedure is to adjust the solvent density by addition of D2O so as to blank out the contribution of bound detergent to the sedimentation potential. An approximate measure of detergent binding can be obtained ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1972
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)44961-2